Genome-wide scan of Flortaucipir PET levels finds JARID2 associated with cerebral tau deposition.

ABSTRACT:

Background

Genetic research on Alzheimer's disease (AD) has primarily focused on amyloid-β (Aβ) pathogenesis, with fewer studies exploring tau pathology. Elucidating the genetic basis of tau pathology could identify novel pathways in AD.

Methods

We conducted a genome-wide association study of tau standard uptake value ratios (SUVRs) from ^[18]F-flortaucipir positron emission tomography (PET) images to identify genetic variants underlying Tau pathology. Genetic data and tau-SUVRs from ^[18]F-flortaucipir PET images were acquired from the A4 (311 with preclinical AD) and ADNI (280 cognitively normal, 76 with mild cognitive impairment, and 19 AD patients) studies. Circulating plasma proteins in UK Biobank Pharma Proteomics Project (UKBPPP, N=54,129) were use

SUBMITTER: Gunasekaran TI 

PROVIDER: S-EPMC11482994 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature