Neuroimaging-Derived Biomarkers of the Antidepressant Effects of Ketamine.

ABSTRACT: Major depressive disorder is a highly prevalent psychiatric disorder. Despite an extensive range of treatment options, about a third of patients still struggle to respond to available therapies. In the last 20 years, ketamine has gained considerable attention in the psychiatric field as a promising treatment of depression, particularly in patients who are treatment resistant or at high risk for suicide. At a subanesthetic dose, ketamine produces a rapid and pronounced reduction in depressive symptoms and suicidal ideation, and serial treatment appears to produce a greater and more sustained therapeutic response. However, the mechanism driving ketamine's antidepressant effects is not yet well understood. Biomarker discovery may advance knowledge of ketamine's antidepressant action, which co

SUBMITTER: Zavaliangos-Petropulu A 

PROVIDER: S-EPMC11483103 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature