BioPred: an R package for biomarkers analysis in precision medicine.

ABSTRACT:

Summary

The R package BioPred offers a suite of tools for subgroup and biomarker analysis in precision medicine. Leveraging Extreme Gradient Boosting (XGBoost) along with propensity score weighting and A-learning methods, BioPred facilitates the optimization of individualized treatment rules to streamline subgroup identification. BioPred also enables the identification of predictive biomarkers and obtaining their importance rankings. Moreover, the package provides graphical plots tailored for biomarker analysis. This tool enables clinical researchers seeking to enhance their understanding of biomarkers and patient population in drug development.

Availability and implementation

The package is available at CRAN and https://github.com/deeplearner0731/BioPred.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11483108 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature