Optimal Antihypertensive Systolic Blood Pressure: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Systolic blood pressure (SBP) lowering reduces major cardiovascular disease (CVD) and all-cause mortality. However, the optimal target for SBP lowering remains controversial.

Methods

We included trials with random allocation to an SBP <130 mm Hg treatment target and CVD as the primary outcome. Data were extracted from each study independently and in duplicate using a standardized protocol. Random-effects meta-analysis was used to obtain pooled hazard ratios (HRs) and 95% CIs for CVD and all-cause mortality comparing SBP <130 and ≥130 mm Hg treatment targets. A secondary analysis compared the same outcomes for randomization to an SBP target of <120 or <140 mm Hg.

Results

Seven trials, including 72 138 participants, met the eligibility criteria. Compared with

SUBMITTER: Whelton PK 

PROVIDER: S-EPMC11483200 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature