Polybrominated diphenyl ethers and gestational weight gain: a multi-center prospective cohort study.

ABSTRACT:

Objective

To evaluate the associations of plasma polybrominated diphenyl ether (PBDE) concentrations in early pregnancy with gestational weight gain (GWG).

Design

Prospective cohort study.

Setting

US-based, multicentre cohort of pregnant women.

Population

We used data from 2052 women without obesity and 397 women with obesity participating in the NICHD Fetal Growth Studies - Singleton Cohort, with first-trimester plasma PBDE concentrations and weight measurements throughout pregnancy.

Methods

We applied generalised linear models and Bayesian kernel machine regression (BKMR) to evaluate both the individual and joint associations of PBDEs with measures of GWG, adjusting for potential confounders.

Main outcome measures

Total GWG (kg), total and trime

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11483211 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature