Peripheral immune function and Alzheimer's disease: a living systematic review and critical appraisal.

ABSTRACT:

Background

A growing body of literature examines the relationship between peripheral immune function and Alzheimer's Disease (AD) in human populations. Our living systematic review summarizes the characteristics and findings of these studies, appraises their quality, and formulates recommendations for future research.

Methods

We searched the electronic databases PubMed, PsycINFO, and Web of Science, and reviewed references of previous reviews and meta-analyses to identify human studies examining the relationship between any peripheral immune biomarkers and AD up to September 7th, 2023. We examined patterns of reported statistical associations (positive, negative, and null) between each biomarker and AD across studies. Evidence for each biomarker was categorized into four gro

SUBMITTER: Li C 

PROVIDER: S-EPMC11483233 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature