Autologous ADSCs with exogenous NPY promotes fracture healing in ovariectomized rats.

ABSTRACT:

Objective

To evaluate the role of autologous adipose-derived stem cells (ADSCs) with exogenous neuropeptide Y (NPY) on osteoporotic fracture healing.

Methods

We established a fracture healing model in ovariectomized rats of osteoporosis. Autologous ADSCs, isolated from rats' subcutaneous adipose tissue, with exogenous NPY were transplanted into the fracture site four times a week. The fracture healing was observiked with X-ray diagnostic techniques, and the rats' tibias were taken out for section-staining and micro-CT scanning 3 and 6 weeks after fracture. Next, we explored the underlying mechanism by which the transplantation contributed to fracture healing.

Results

Co-culture and co-transplantation of ADSCs with NPY could stimulate the osteoporotic fracture healing.

SUBMITTER: Liu H 

PROVIDER: S-EPMC11483299 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature