Telomere-related prognostic signature for survival assessments in lung adenocarcinoma.

ABSTRACT:

Background

Telomere-related genes (TRGs) are important in many different types of cancers. However, there is a lack of research on the relationship between their expression and prognosis in lung adenocarcinoma (LUAD) patients. This study is to investigate the prognostic value of TRGs in LUAD and to develop a TRG signature that can predict patient survival.

Methods

A total of 2,086 TRGs were obtained from a database of genes involved in telomere maintenance (TelNet), while the clinical information and tumor RNA expression profiles of 513 LUAD patients were acquired from The Cancer Genome Atlas (TCGA) database. Statistical methodologies, such as least absolute shrinkage and selection operator (LASSO)-Cox, were employed to construct a prognostic model with predictive capabiliti

SUBMITTER: Lin H 

PROVIDER: S-EPMC11483338 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature