Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation.

ABSTRACT:

Background

Although the therapeutic effects of berberine have received some attention in recent years, its potential mechanisms underlying its action against stomach carcinoma (SC) remain unclear. In this study, we aimed to elucidate the mechanisms underlying the effects of berberine against SC using a network pharmacology and experimental verification approach.

Methods

Several publicly available databases were used to collect the targets of berberine and SC. Protein-protein interaction (PPI) network, enrichment analyses and molecular docking were performed based on the potential targets of berberine against SC. The potential clinical significance and prognostic value of the targets were predicted by using nomogram and receiver operating characteristic (ROC) analyses. Then t

SUBMITTER: Wang M 

PROVIDER: S-EPMC11483340 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature