Prognosis and progression of phagocytic regulatory factor-related gene combinations in clear cell renal cell carcinoma (ccRCC).

ABSTRACT:

Background

Developing signatures based on specific characteristics to predict prognosis has become a research hotspot in oncology. However, the prognostic value of phagocytosis regulators in clear cell renal cell carcinoma (ccRCC) remains unclear. The aim of the present study was to investigate the prognostic significance of phagocytosis regulators in ccRCC by constructing a prognostic model related to phagocytosis regulators, and to use this model to evaluate the prognosis and treatment effects in ccRCC patients.

Methods

Firstly, kidney renal clear cell carcinoma (KIRC) transcriptome data (RNA-Seq) and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database. Based on literatures PMID 34497417 and PMID 30397336, 167 of the 173 phagocytosis regulator genes

SUBMITTER: Xiao R 

PROVIDER: S-EPMC11483360 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature