Mendelian randomization study on simvastatin and gastric cancer: exploring the therapeutic potential of statins in oncology.

ABSTRACT:

Background

Gastric cancer ranks as the fifth most prevalent cancer and the third leading cause of cancer-related mortality worldwide, Statins, renowned for their cholesterol-lowering effects, have garnered interest for their potential roles in cancer prevention and treatment due to their pleiotropic effects, such as anti-proliferative, pro-apoptotic, and anti-inflammatory properties. This study aims to investigate the therapeutic potential of simvastatin, a widely prescribed statin, in the context of gastric cancer using Mendelian randomization (MR) to explore a possible causal relationship between simvastatin use and gastric cancer risk.

Methods

We conducted a two-sample MR analysis utilizing summary statistics from genome-wide association studies (GWAS). Data from the Inte

SUBMITTER: Wang J 

PROVIDER: S-EPMC11483371 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature