TGF-β signaling-related signature for predicting prognosis and therapeutic response in lower-grade glioma.

ABSTRACT:

Background

Low-grade glioma (LGG) is a tumor that includes World Health Organization (WHO) grade II and III glioma, the treatment of which consistently results in relapse and drug resistance. Transforming growth factor-beta (TGF-β) is a multifunctional cytokine that regulates various cellular processes, which is found to be abnormal in tumors and promotes glioma development and progression. In this study, we aimed to systematically evaluate the importance of the genes associated with TGF-β in LGG and discover the role of these genes in the prognosis and treatment response of LGG.

Methods

We used the "Bioconductor Limma" and "consensusClusterplus" R packages to screen differential and prognostic TGF-β-related genes. The R package "GSVA" was used to estimate the infiltration o

SUBMITTER: Yan J 

PROVIDER: S-EPMC11483406 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature