TCF4 as a potential prognostic biomarker and an anticancer target in gastric cancer.

ABSTRACT:

Background

Lymphoid enhancer-binding factor 1 (LEF1)/T cell factor (TCF) family members are key transcription factors in malignant tumors. In this study, the role of T cell factor 4 (TCF4) in the progression of gastric cancer (GC) cell migration and invasion was investigated.

Methods

Fifty-five pairs of GC tissues and adjacent non-tumor tissues were collected for evaluating the expression of LEF1/TCF family members, which were also evaluated by the Gene Expression Profiling Interactive Analysis (GEPIA) database, an online analysis platform based on The Cancer Genome Atlas and Genotype-Tissue Expression databases.

Results

Through GEPIA online analysis and our experimental specimens, we found that TCF4 messenger RNA (mRNA) expression was significantly upregulated

SUBMITTER: Wang H 

PROVIDER: S-EPMC11483414 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature