RNA sequencing reveals transcriptomic changes in PC-12 cells following plasminogen activator, tissue type overexpression.

ABSTRACT:

Background

Pheochromocytoma and paraganglioma, collectively known as PPGL, are categorized as neuroendocrine tumors with the potential for malignancy. Plasminogen activator, tissue type (PLAT) is a protein encoding gene that encodes tissue-type plasminogen activator, which converts plasminogen to plasmin. There is limited research on the association between PLAT and PPGL. Previous studies have only found that the expression level of PLAT protein is significantly increased in PPGL with deficient blood supply, and its role in the occurrence and progression of PPGL remains unclear and needs further clarification. The purpose of this study is to provide some new clues to elucidate the role of PLAT in PPGL, in order to better guide future research directions.

Methods

The PC-12 ce

SUBMITTER: Mao Y 

PROVIDER: S-EPMC11483446 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature