Arterial to jugular-bulb lactate difference in patients undergoing elective brain tumor craniotomy.

ABSTRACT: Hyperlactatemia is common during tumor craniotomy, but the underlying pathophysiology is unclear. This study measured simultaneous arterial and jugular-bulb lactate concentrations in patients undergoing brain tumor craniotomy to investigate the hypothesis that hyperlactatemia was associated with a net cerebrovascular lactate input. In 20 patients, arterial and jugular-bulb blood was collected hourly from the start of surgery to 6 h postoperatively for measurement of lactate, glucose, and oxygen concentration. For each marker, data were analyzed using a linear mixed-effects model with jugular-bulb concentration as dependent variable, arterial concentration as fixed effect, and patient as random effect. Furthermore, we generated regression lines between arterial and jugular-bulb concentratio

SUBMITTER: Vassilieva A 

PROVIDER: S-EPMC11483513 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature