Insight into prostate cancer osteolytic metastasis by RelB coordination of IL-8 and S100A4.

ABSTRACT:

Background

Although RANK-LRANK interaction is essential for osteoclastogenesis, the mechanisms by which cancer cells invade bone tissues and initiate osteolytic metastasis remain unclear. Here, we show that the hyperactivation of RelB fosters prostate cancer (PCa) osteolytic metastasis by coordinating interleukin-8 (IL-8) and calcium-binging protein A4 (S100A4).

Methods

The factors promoting PCa bone metastasis were investigated in sera from PCa patients and tumour tissues derived from nude mice using immunohistochemical analysis and enzyme-linked immunosorbent assays (ELISA). Cell mobility and mineralization were quantified using BioStation CT and Osteolmage assay. The relative cistrome was investigated in advanced PCa cells by standard transcriptional analyses, including t

SUBMITTER: Sun W 

PROVIDER: S-EPMC11483529 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature