Risk factors for major bleeding in patients with atrial fibrillation and CKD G3-G5D on oral anticoagulants.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) and atrial fibrillation (AF) on oral anticoagulants (OACs) are at high risk of bleeding. Determinants of major bleeding risk in OAC users with AF and CKD are not well established and available bleeding score systems do not perform well in CKD. This study aims to present risk factors associated with major bleeding in a Swedish cohort of OAC-treated patients with CKD G3-5D.

Methods

We conducted a Swedish register-based cohort study including patients with AF and CKD G3-5D on warfarin or direct OACs (DOACs) between 2009 and 2018. Data were collected from high-quality registers including the Swedish Renal Registry and Auricula, a register for AF and OACs. Risk factors for major bleeding were investigated with Cox regression a

SUBMITTER: Welander F 

PROVIDER: S-EPMC11483581 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature