Single-cell transcriptome analysis reveals evolving tumour microenvironment induced by immunochemotherapy in nasopharyngeal carcinoma.

ABSTRACT:

Background

Combinatory therapeutic strategy containing immunochemotherapy as part of induction therapy components is one of the current trends in the treatment of high-risk metastatic locally advanced nasopharyngeal carcinoma (NPC). However, the mechanism underlying the heterogeneity of response at the single-cell level has not been underexplored.

Methods

18 bulks and 11 single-cell RNA sequencing from paired before-treatment and on-treatment samples in patients with treatment-naive high-risk metastatic locally advanced NPCs were obtained. Following quality control, a total of 87 191 cells were included in the subsequence bioinformatics analysis.

Results

Immunochemotherapy was associated with on-treatment tumour microenvironment (TME) remodelling, including upregulati

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11483602 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature