Decipher 'Em All: A Profiling Study on the Effects of Acyl Groups in <i>O</i>-Acyl-ω-hydroxy Fatty Acids.

ABSTRACT: The O-acyl-ω-hydroxy fatty acids (OAHFAs) are an intriguing class of surface-active lipids which can be found in the human tear film lipid layer (TFLL). Recent studies have suggested that OAHFAs exist in the polar lipid layer and play a central role in TFLL function. Surprisingly, biophysical profiling studies have only shed light on the properties of OAHFAs bearing an oleate acyl group and insights on species with other acyl groups are scarce. Herein, we seek to address this issue through (1) focusing on the synthesis and characterization of a representative library of OAHFA analogues bearing a palmitate, palmitoleate, stearate, and linoleate acyl group, and (2) performing an in-depth mapping of their biophysical properties. Our results indicate that NMR-spectroscopic techniques ca

SUBMITTER: Stubb H 

PROVIDER: S-EPMC11483765 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature