Alterations of the gut microbiome in HIV infection highlight human anelloviruses as potential predictors of immune recovery.

ABSTRACT:

Background

HIV-1 infection is characterized by a massive depletion of mucosal CD4 T cells that triggers a cascade of events ultimately linking gut microbial dysbiosis to HIV-1 disease progression and pathogenesis. The association between HIV infection and the enteric virome composition is less characterized, although viruses are an essential component of the gut ecosystem. Here, we performed a cross-sectional analysis of the fecal viral (eukaryotic viruses and bacteriophages) and bacterial microbiome in people with HIV (PWH) and in HIV-negative individuals. To gain further insight into the association between the gut microbiome composition, HIV-associated immunodeficiency, and immune recovery, we carried out a longitudinal study including 14 PWH who initiated antiretroviral therapy

SUBMITTER: Boukadida C 

PROVIDER: S-EPMC11483978 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature