Case report: Rapid symptom relief in autoimmune encephalitis with efgartigimod: a three-patient case series.

ABSTRACT:

Introduction

Autoimmune encephalitis (AE) comprises a group of inflammatory brain disorders mediated by autoimmune responses. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis, and anti-γ-aminobutyric acid-B receptor (GABABR) encephalitis are the most prevalent forms, characterized by the presence of antibodies against neuronal cell-surface antigens. Efgartigimod, an antagonist of the neonatal Fc receptor, has proven efficacy in myasthenia gravis treatment. This clinical case report describes the clinical progression and functional outcomes of AE in three patients who received efgartigimod treatment.

Case presentations

Case 1 was a 60-year-old man exhibiting memory impairment and psychiatric disturbances over

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11484013 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature