Comparative genomics of the Natural Killer Complex in carnivores.

ABSTRACT:

Background

The mammalian Natural Killer Complex (NKC) harbors genes and gene families encoding a variety of C-type lectin-like proteins expressed on various immune cells. The NKC is a complex genomic region well-characterized in mice, humans and domestic animals. The major limitations of automatic annotation of the NKC in non-model animals include short-read based sequencing, methods of assembling highly homologous and repetitive sequences, orthologues missing from reference databases and weak expression. In this situation, manual annotations of complex genomic regions are necessary.

Methods

This study presents a manual annotation of the genomic structure of the NKC region in a high-quality reference genome of the domestic cat and compares it with other felid species and wit

SUBMITTER: Futas J 

PROVIDER: S-EPMC11484026 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature