Impaired neutrophil-mediated cell death drives Ewing's Sarcoma in the background of Down syndrome.

ABSTRACT:

Introduction

Ewing Sarcoma (EWS) has been reported in seven children with Down syndrome (DS). To date, a detailed assessment of this solid tumour in DS patients is yet to be made.

Methods

Here, we characterise a chemo-resistant mediastinal EWS in a 2-year-old DS child, the youngest ever reported case, by exploiting sequencing approaches.

Results

The tumour showed a neuroectodermal development driven by the EWSR1-FLI1 fusion. The inherited myeloperoxidase deficiency of the patient caused failure of neutrophil-mediated cell death and promoted genomic instability.

Discussion

In this context, the tumour underwent genome-wide near haploidisation resulting in a massive overexpression of pro-inflammatory cytokines. Recruitment of defective neutrophils fostered rapid e

SUBMITTER: Peirone S 

PROVIDER: S-EPMC11484044 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature