A mathematical model for simulation of cardiovascular, renal, and hormonal responses to burn injury and resuscitation.

ABSTRACT:

Introduction

Treating extensive burn injury requires an individually tailored resuscitation protocol that includes hourly-titrated intravenous fluid infusion to avert both hypovolemic shock and edema. Due to the complexity of burn pathophysiology and significant variability in treatment protocols, there is an ongoing effort to optimize burn resuscitation. The goal of this work is to contribute to this effort by developing a mathematical model of burn pathophysiology and resuscitation for in silico testing of burn resuscitation protocols and decision-support systems.

Methods

In our previous work, we developed and validated a mathematical model consisting of volume kinetics, burn-induced perturbations, and kidney function. In this work, we expanded our previous mathemat

SUBMITTER: ArabiDarrehDor G 

PROVIDER: S-EPMC11484069 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature