Investigation of parasite genetic variation and systemic immune responses in patients presenting with different clinical presentations of cutaneous leishmaniasis caused by Leishmania aethiopica.

ABSTRACT:

Background

Cutaneous leishmaniasis (CL) is a neglected tropical skin disease, caused by the protozoan parasite Leishmania. In Ethiopia, CL is mainly caused by Leishmania aethiopica and can present in different clinical forms. The aim of this study was to assess whether these different forms are associated with differences in parasite genetic and host systemic immune signatures.

Methods

Here we analysed the whole genome sequence data for 48 clinical parasite isolates and the systemic immune signature from a cohort of CL patients, who were recruited in Nefas Mewcha, Northern Ethiopia, from January 2019 to January 2022.

Results

Our results show that parasites from CL cases with different presentations in a single Ethiopian setting are from the same genetic population bas

SUBMITTER: Yizengaw E 

PROVIDER: S-EPMC11484111 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature