Acetylcysteine synergizes PD-1 blockers against colorectal cancer progression by promoting TCF1⁺PD1⁺CD8⁺ T cell differentiation.

ABSTRACT:

Background

Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, some patients with CRC do not respond well to immunotherapy, possibly due to the exhaustion of CD8⁺ T cells in the tumor microenvironment. N-Acetylcysteine (NAC) can reduce CD8⁺ T cell exhaustion in vitro and induce their differentiation into long-lasting phenotypes, thus enhancing the anti-tumor effect of adoptive T cell transfer. However, whether NAC can be combined with PD-1 blockade in CRC treatment and how NAC regulates CD8⁺ T cell differentiation remain unclear. Hence, in this study, we aimed to investigate whether NAC has a synergistic effect with PD-1 blockers against CRC progression.

Methods

We constructed

SUBMITTER: Zhou W 

PROVIDER: S-EPMC11484120 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature