Circulating methylated <i>HOXA9</i> tumor DNA as a biomarker for mortality in recurrent breast cancer: An exploratory study.

ABSTRACT: Methylated homeobox A9 (meth-HOXA9) circulating tumor DNA may be a relevant biomarker in breast cancer, although its clinical significance remains unknown. The present exploratory study aimed to investigate the association between meth-HOXA9 and mortality in patients with recurrent breast cancer. The cohort study enrolled 51 patients with breast cancer recurrence from the Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark (Vejle, Denmark). Tissue samples from primary surgery and biopsies, and plasma samples obtained at the time of recurrence were analyzed for meth-HOXA9 using a methylation-specific droplet digital polymerase chain reaction. Using Cox regression, hazard ratios (HRs) for mortality with 95% confidence intervals (CIs) comparing

SUBMITTER: Bakkensen Bruun S 

PROVIDER: S-EPMC11484173 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature