Potential neuroendocrine differentiation in poorly differentiated colorectal adenocarcinoma: A hidden trait?

ABSTRACT: Neuroendocrine carcinoma (NEC) of the colon and rectum is a rare malignancy with a poor prognosis that is characterized by distinct clinical and histopathological features that differ significantly from those of more prevalent adenocarcinomas. Poorly differentiated colorectal adenocarcinoma (PDC) is also rare and carries a poor prognosis. Considering the morphological similarities between these two rare, poorly differentiated cancers of the colon and rectum, it is plausible that certain cases of colorectal cancer (CRC) diagnosed as PDC may contain NEC as well. In the present study, cases of CRC that were diagnosed as PDC at our institution were investigated, searching for patients who exhibited NEC characteristics based on the expression of neuroendocrine markers (NEMs), including chromogr

SUBMITTER: Rong Y 

PROVIDER: S-EPMC11484215 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature