Active fraction of ground cherry (<i>Physalis angulata</i> L.) calyces attenuates azoxymethane dextran sulfate sodium‑induced colon carcinogenesis in mice.

ABSTRACT: Physalis angulata L., commonly known as wild tomato or ground cherry, is widely used in tropical and subtropical areas to treat health disorders including inflammation, hepatitis, dermatitis, cancer and diabetes. In Colombia, anti-cancer and anti-inflammatory activity are the most common ethnopharmacological applications of P. angulata calyces. P. angulata dichloromethane fraction (PADF) has significant anti-inflammatory activity. The present study assessed the pharmacological effect of PADF on colorectal cancer (CRC) using cancer and normal human cells and an azoxymethane (AOM)/dextran sulfate sodium (DSS) murine model. MTT and clonogenic assay, cell cycle and apoptosis analysis and mitochondrial membrane potential measurement were employed to evaluate in vitro

SUBMITTER: Ocampo Y 

PROVIDER: S-EPMC11484217 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature