Mechanism of biliary atresia caused by T follicular helper cells-induced immune injury.

ABSTRACT:

Background

Biliary atresia (BA) has diverse and unclear pathogenesis, which may be related to immune response in response to a foreign stimulus. T follicular helper (Tfh) cells have been found to play an important role in various immune diseases.

Aims

To investigate the expression of Tfh cells in BA and non-BA cholestatic diseases in children.

Methods

Transcriptome sequencing and Gene Ontology (GO) enrichment analysis were performed to investigate the differences in gene expression between the BA group and the non-BA cholestasis group. Study the distribution of Tfh cells in liver tissues of the BA and non-BA cholestatic groups through single sample gene set enrichment analysis (ssGSEA). Tfh cells (CD3⁺Bcl6⁺) in liver tissues from BA patients were

SUBMITTER: Ji Z 

PROVIDER: S-EPMC11484220 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature