The causality between rheumatoid arthritis and postural deformities: bidirectional Mendelian randomization study and mediation analysis.

ABSTRACT:

Background

To better understand the preventive or therapeutic clinical interventions that may be supported by the association between rheumatoid arthritis (RA) and postural deformities including hallux valgus, flat foot, and scoliosis, this study was conducted using Mendelian randomization (MR) analysis. It aimed to investigate whether RA is causally associated with postural deformities in European populations.

Methods

Summary-level data on RA and postural deformities were obtained from the IEU OpenGWAS project and Finngen database, respectively. LDSC regression analysis was conducted to assess the genetic correlation between these diseases. The inverse variance weighting (IVW) method was employed as the primary approach for two-sample MR analyses to evaluate causality. Supp

SUBMITTER: Zhao P 

PROVIDER: S-EPMC11484279 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature