Adherence to a low-fat dietary pattern reduces head and neck cancer risk: evidence from the PLCO trial.

ABSTRACT:

Purpose

Low-fat dietary (LFD) pattern refers to a dietary structure with reduced fat intake. The aim was to investigate the association between LFD pattern and risk of head and neck cancer (HNC).

Methods

Data were derived from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. LFD score was used to assess adherence to an LFD pattern, with higher scores indicating greater adherence. Cox regression was used to evaluate the association between LFD score and risk of HNC and its subtypes. To visualize the trend in risk of HNC and its subtypes with changing LFD score, restricted cubic spline plots were utilized. A series of subgroup analyses were conducted to identify potential confounders. Sensitivity analyses were performed to assess the robustness of the

SUBMITTER: Wang R 

PROVIDER: S-EPMC11484361 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature