Hypermethylation of the sodium channel beta subunit gene promoter is associated with colorectal cancer.

ABSTRACT:

Aims

To better understand the role of sodium channel beta subunit (SCNN1B) in the initiation and progression of colorectal cancer (CRC) and to identify potential biomarkers for the early detection and prognosis of CRC.

Methods

A total of 74 pairs of CRC tissues and their adjacent normal tissues were collected between October 2016 and November 2017. The methylation levels of the SCNN1B promoter region in CRC tissues and their adjacent normal tissues were investigated by pyrosequencing. The expression of both SCNN1B mRNA and protein were detected by RT‒qPCR and immunohistochemistry, respectively.

Results

The results showed that the methylation levels of the SCNN1B promoter region were significantly higher in CRC tissues than in adjacent normal tissues. The expression le

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11484387 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature