Sex-specific phenotypical, functional and metabolic profiles of human term placenta macrophages.

ABSTRACT:

Background

Placental macrophages, Hofbauer cells (HBC) are the only fetal immune cell population within the stroma of healthy placenta along pregnancy. They are central players in maintaining immune tolerance during pregnancy. Immunometabolism emerged a few years ago as a new field that integrates cellular metabolism with immune responses, however, the immunometabolism of HBC has not been explored yet. Here we studied the sex-specific differences in the phenotypic, functional and immunometabolic profile of HBC.

Methods

HBC were isolated from human term placentas (N = 31, 16 from male and 15 female neonates). Ex vivo assays were carried out to assess active metabolic and endoplasmic reticulum stress pathways by flow cytometry, confocal microscopy, gene expression and in silic

SUBMITTER: Paparini DE 

PROVIDER: S-EPMC11484421 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature