Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery.

ABSTRACT:

Background

Although numerous studies have shown that bariatric surgery results in sustained weight loss and modifications in gut microbiota composition and cognitive function, the exact underlying mechanisms are unclear. This study aimed to investigate the effects of bariatric surgery on cognitive function through the microbiota-gut-brain axis (MGBA).

Methods

Demographic data, serum samples, fecal samples, cognitive assessment scales, and resting-state functional connectivity magnetic resonance imaging (rs-fMRI) scans were obtained from 39 obese patients before and after (6 months) laparoscopic sleeve gastrectomy (LSG). PCA analysis, OPLS-DA analysis, and permutation tests were used to conduct fecal 16 S microbiota profiling, serum metabolomics, and neuroimaging analyses, an

SUBMITTER: Xiang Q 

PROVIDER: S-EPMC11484437 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature