Assessment of the effects of cannabidiol and a CBD-rich hemp extract in <i>Caenorhabditis elegans</i>.

ABSTRACT: Consumer use of cannabidiol (CBD) is growing, but there are still data gaps regarding its possible adverse effects on reproduction and development. Multiple pathways and signaling cascades involved in organismal development and neuronal function, including endocannabinoid synthesis and signaling systems, are well conserved across phyla, suggesting that Caenorhabditis elegans can model the in vivo effects of exogenous cannabinoids. The effects in C. elegans on oxidative stress response (OxStrR), developmental timing, juvenile and adult spontaneous locomotor activity, reproductive output, and organismal CBD concentrations were assessed after exposure to purified CBD or a hemp extract suspended in 0.5% sesame oil emulsions. In C. elegans, this emulsion vehicle is e

SUBMITTER: Camacho JA 

PROVIDER: S-EPMC11484448 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature