Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis.

ABSTRACT:

Background/ aim

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons, causing progressive atrophy of muscles, hypertonia, and paralysis. This study aimed to evaluate the current evidence and effectiveness of ultrasound in investigating nerve cross-sectional area (CSA) of peripheral nerves, vagus and cervical roots in those with ALS compared with healthy controls and to pool the CSA measurements.

Methods

A systematic search was conducted on Cochrane, Clarivate Web of Science, PubMed, Scopus, and Embase for the mesh terms nerve, ultrasonography, and amyotrophic lateral sclerosis. A quality assessment was performed using the New-Ottawa scale. In addition, a double-arm meta-analysis using Review Manager 5 software version 5.4

SUBMITTER: Abdelnaby R 

PROVIDER: S-EPMC11484457 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature