Effect of Sinetrol^® Xpur on metabolic health and adiposity by interactions with gut microbiota: a randomized, open label, dose-response clinical trial.

ABSTRACT:

Background

Sinetrol^® Xpur is a polyphenolic ingredient rich in citrus flavonoids that has shown weight loss effects in previous studies. The dose dependent nature, gut microbial actions of this product has not been explored previously, thus presented in this study.

Methods

In this open label study, we evaluated the effect of Sinetrol^® Xpur supplementation on healthy but overweight/obese adults (20-50 yrs) for 16 weeks. Participants (n = 20) were randomly allocated to a high dose group (HD, 1800 mg/day) or low dose group (LD, 900 mg/day) of the product for 16 weeks. Fat composition, gut microbial composition, were evaluated using MRI and 16S rDNA sequencing respectively at week 1 and 16.

Results

We observed HDL, HbA1C, LDL and leptin improved sign

SUBMITTER: Muralidharan J 

PROVIDER: S-EPMC11484468 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature