The use of plasma exchange with albumin replacement in the management of Alzheimer's disease: a scoping review.

ABSTRACT:

Introduction

AD is a progressive neurodegenerative disorder causing significant cognitive decline and impaired daily functioning. Current treatments offer only modest relief, and many amyloid-targeting therapies have failed, prompting exploration of alternative approaches such as PE with albumin replacement.

Objectives

This scoping review systematically maps the literature on PE with albumin replacement in AD management, focusing on outcomes, methodologies, and reported benefits and risks.

Methods

A comprehensive search in PubMed, supplemented by reference scanning and hand-searching, identified studies involving PE with albumin replacement in AD patients. Data charting and critical appraisal were conducted using standardized tools.

Results

Seven primary studie

SUBMITTER: Cantero-Fortiz Y 

PROVIDER: S-EPMC11484623 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature