Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function.

ABSTRACT:

Background

Lower skeletal muscle mitochondrial function is associated with future cognitive impairment and mobility decline, but the biological underpinnings for these associations are unclear. We examined metabolomic markers underlying skeletal muscle mitochondrial function, cognition and motor function.

Methods

We analysed data from 560 participants from the Baltimore Longitudinal Study of Aging (mean age: 68.4 years, 56% women, 28% Black) who had data on skeletal muscle oxidative capacity (post-exercise recovery rate of phosphocreatine, kPCr) via 31P magnetic resonance spectroscopy and targeted plasma metabolomics using LASSO model. We then examined which kPCr-related markers were also associated with cognition and motor function in a larger sample (n = 918, mean age: 69.

SUBMITTER: Tian Q 

PROVIDER: S-EPMC11484644 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature