Tumor immune microenvironment analysis of non-small cell lung cancer development through multiplex immunofluorescence.

ABSTRACT:

Background

Emerging evidence has underscored the crucial role of infiltrating immune cells in the tumor immune microenvironment (TIME) of non-small cell lung cancer (NSCLC) development and progression. With the implementation of screening programs, the incidence of early-stage NSCLC is rising. However, the high risk of recurrence and poor survival rates associated with this disease necessitate a deeper understanding of the TIME and its relationship with driver alterations. The aim of this study was to provide an in-depth analysis of immune changes in early-stage NSCLC, highlighting the significant transitions in immune response during disease progression.

Methods

Tumor tissues were collected from 105 patients with precancerous lesions or stage I-III NSCLC. Next-generation se

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11484713 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature