TFAP2A-activated ITGB4 promotes lung adenocarcinoma progression and inhibits CD4⁺/CD8⁺ T-cell infiltrations by targeting NF-κB signaling pathway.

ABSTRACT:

Background

Immune-associated genes play vital roles in the tumorigenesis, progression and immunotherapy responses of malignant tumors. This study aimed to comprehensively evaluate the role and mechanism of novel immune-associated gene integrin β4 (ITGB4) in the progression and immune microenvironment of lung adenocarcinoma (LUAD).

Methods

There were 770 immune-associated genes curated from NanoString PanCancer Immune Profiling Panel. Differentially expressed immune-related genes were initially screened using transcriptome data from 57 paired LUAD samples in The Cancer Genome Atlas (TCGA) and 15 paired LUAD samples in GSE31210, and were further validated in 19 paired LUAD samples from our institution. Log-rank test was adopted to identify LUAD prognosis associated gene

SUBMITTER: Pan C 

PROVIDER: S-EPMC11484716 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature