A multi-level investigation of the genetic relationship between gastroesophageal reflux disease and lung cancer.

ABSTRACT:

Background

Observational studies have revealed a potential association between gastroesophageal reflux disease (GERD) and lung cancer (LC), but the genetic role in their comorbidity have not been fully elucidated. This study aimed to comprehensively dissect the genetic link underlying GERD and LC.

Methods

Using large-scale genome-wide association study (GWAS) data, we investigated shared genetic architecture between GERD and LC. Our analyses encompassed genetic correlation, cross-trait meta-analysis, transcriptome-wide association studies (TWASs), and the evaluation of the causality though a bidirectional Mendelian randomization (MR) analysis with sufficient sensitivities.

Results

We identified a significant genome-wide genetic correlation between GERD and overall LC (<

SUBMITTER: Wu D 

PROVIDER: S-EPMC11484728 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature