Genetic characteristics of clinical carbapenem-resistant Klebsiella pneumoniae: epidemic ST11 KPC-2-producing strains and non-negligible NDM-5-producing strains with diverse STs.

ABSTRACT: Klebsiella pneumoniae is among the most important Gram-negative pathogens that can cause serious nosocomial infections. The emergence and prevalence of hypervirulent carbapenem-resistant K. pneumoniae (Hv-CRKP) pose a significant challenge to public health. In this study, we characterized thirty carbapenem-resistant K. pneumoniae (CRKP) strains from a tertiary care hospital in Sichuan province, China, by whole-genome sequencing and genome analysis. These strains were all highly resistant to carbapenem but remained susceptible to tigecycline. Of the 30 tested CRKP strains, 23 were positive for bla_KPC-2 and seven for bla_NDM-5. These bla_KPC-2-positive strains all belonged to ST11, while bla_NDM-5-positive strains belonged to five distinct STs. Phylog

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC11484748 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature