Engineered cross-feeding creates inter- and intra-species synthetic yeast communities with enhanced bioproduction.

ABSTRACT: Microorganisms can be engineered to sustainably produce a variety of products including fuels, pharmaceuticals, materials, and food. However, highly engineered strains often result in low production yield, due to undesired effects such as metabolic burden and the toxicity of intermediates. Drawing inspiration from natural ecosystems, the construction of a synthetic community with division of labor can offer advantages for bioproduction. This approach involves dividing specific tasks among community members, thereby enhancing the functionality of each member. In this study, we identify six pairs out of fifteen composed of six auxotrophs of Yarrowia lipolytica that spontaneously form robust syntrophic and synergistic communities. We characterize the stability and growth dynamics of these com

SUBMITTER: Park YK 

PROVIDER: S-EPMC11484764 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature