Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa.

ABSTRACT: Macrolides are widely used antibiotics for the treatment of bacterial airway infections. Due to its elevated minimum inhibitory concentration in standardized culture media, Pseudomonas aeruginosa is considered intrinsically resistant and, therefore, antibiotic susceptibility testing against macrolides is not performed. Nevertheless, due to macrolides' immunomodulatory effect and suppression of virulence factors, they are used for the treatment of persistent P. aeruginosa infections. Here, we demonstrate that macrolides are, instead, effective antibiotics against P. aeruginosa airway infections in an Air-Liquid Interface (ALI) infection model system resembling the human airways. Importantly, macrolide treatment in both people with cystic fibrosis and primary ciliary dyskinesia patients lead

SUBMITTER: Goltermann L 

PROVIDER: S-EPMC11484784 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature