The dynamics of bla_TEM resistance genes in Salmonella Typhi.

ABSTRACT: Salmonella Typhi (S. Typhi) is an important pathogen causing typhoid fever worldwide. The emergence of antibiotic resistance, including that of bla_TEM genes encoding to TEM [Formula: see text]-lactamases has been observed. This study aimed to investigate the dynamics of bla_TEM genes in S. Typhi by analyzing the phylogeny and flanking region patterns and phylogenetic associating them with metadata (year, country) and genomic data (genotypes, antibiotic resistance genes (ARGs), plasmids). Genomic sequences of publicly available S. Typhi harboring bla_TEM (n = 6079), spanning from 1983 to 2023, were downloaded and analyzed using CSIPhylogeny for phylogeny, Flankophile for identifying genetic contexts around bla_TEM genes and GenoTyphi for determining

SUBMITTER: Nuanmuang N 

PROVIDER: S-EPMC11484844 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature