The Upper Limit of Normal Rate of Lung Function Decline in Healthy Adults in the Framingham Heart Study.

ABSTRACT:

Background

Lung function declines over the course of adulthood; however, a consensus on the normal range of decline in an individual's lung function is lacking.

Research question

What is the normal range and the upper limit of normal (ULN) decline in lung function in adults without prior tobacco use, occupational dust exposure, or a known diagnosis or symptoms of cardiopulmonary disease?

Study design and methods

A retrospective analysis of healthy individuals who have never smoked (N = 1,305) from the Framingham Heart Study with repeated lung function meeting standards for acceptability and reproducibility was conducted. Longitudinal change was derived using a linear mixed effects model and estimated to a 6-year interval. The ULN decline was defined as the 95th percen

SUBMITTER: Sangani R 

PROVIDER: S-EPMC11484874 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature