Perturbations in inflammatory pathways are associated with shortness of breath profiles in oncology patients receiving chemotherapy.

ABSTRACT:

Purpose

One plausible mechanistic hypothesis is the potential contribution of inflammatory mechanisms to shortness of breath. This study was aimed to evaluate for associations between the occurrence of shortness of breath and perturbations in inflammatory pathways.

Methods

Patients with cancer reported the occurrence of shortness of breath six times over two cycles of chemotherapy. Latent class analysis was used to identify subgroups of patients with distinct shortness of breath occurrence profiles (i.e., none (70.5%), decreasing (8.2%), increasing (7.8%), high (13.5%)). Using an extreme phenotype approach, whole transcriptome differential gene expression and pathway impact analyses were performed to evaluate for perturbed signaling pathways associated with shortness of brea

SUBMITTER: Shin J 

PROVIDER: S-EPMC11484916 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature