Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity.

ABSTRACT:

Significance

TDO2 is more highly expressed than the nonhomologous TRP-catabolizing enzyme IDO1 in TNBC. We find that TDO2 knockdown can lead to a compensatory increase in IDO1. Therefore, we tested a newly developed TDO2/IDO1 dual inhibitor and found that it decreases TRP catabolism, anchorage-independent survival, and invasive capacity.

SUBMITTER: Kuo LW 

PROVIDER: S-EPMC11484926 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature